Padres vs. Diamondbacks, September 25, 2026 — Pfaadt for Arizona, Mize for San Diego

On September 25, 2026, San Diego’s Petco Park hosted the matchup between the San Diego Padres and the Arizona Diamondbacks. Starting for Arizona was RHP Brandon Pfaadt (7-3, 3.72 ERA), while SP Casey Mize (6-9, 3.96 ERA) took the mound for the Padres. On the injured list for San Diego were reliever R. Thompson (back, 60-day IL) and T. Locklear (finger, 60-day IL). Arizona reported absences including L. Giolito (arm/elbow, 60-day IL), G. Sheets (leg, 10-day IL), L. Rengifo (knee, 60-day IL), M. Andújar (wrist, 10-day IL) and R. Laureano (groin, 60-day IL).

As Bleacher Report reports, the two teams came in with different season records: Arizona 85-74 and San Diego 89-70. The Arizonans played as visitors, while the Padres had a strong home record; in the basic stat lines, Arizona showed a batting average around .246 and San Diego around .243. Individually, Nolan Arenado and Manny Machado had each hit 29 home runs for their teams, ranking among the season’s offensive leaders.

According to Bleacher Report, the Petco Park meeting mattered for both sides on the eve of the season’s final stretch, with implications for standings and for planning rotation and bullpen schemes for upcoming games.