San Francisco 49ers lead Arizona Cardinals 23-6 in the third quarter

On September 27, 2026, the San Francisco 49ers are leading the Arizona Cardinals, 23-6, with 9:50 remaining in the third quarter. The 49ers scored 7 points in the first quarter, 10 in the second and 6 in the third, while the Cardinals have only 6 points scored in the first half. The Cardinals are currently in possession, 1st & 10 at the 49ers’ 44-yard line after a drive that gained 25 yards and 1:17 on the clock.

As Bleacher Report reports, during the game it was reported that 49ers wide receiver Mike Evans was carted off due to a rib-area concern and was later ruled out. Also, according to earlier reports, defensive end Nick Bosa is expected to miss several weeks due to a calf issue, but is not expected to be placed on the injured list.

Christian McCaffrey scored a touchdown from one yard, leaping over the pile of the defense, and it was his 101st career touchdown, giving the 49ers the lead. After Eddy Piñeiro’s failed extra-point attempt, the score remained 23-6 in favor of San Francisco.

The game continues with the 49ers controlling the pace so far, while the Cardinals look to fight back from the current possession. For live updates, statistics and further analysis, see Bleacher Report’s coverage.